Urine protein:creatinine ratio vs 24-hour urine protein for proteinuria management: analysis from the phase 3 REFLECT study of lenvatinib vs sorafenib in hepatocellular carcinoma.

ABSTRACT:

Background

Proteinuria monitoring is required in patients receiving lenvatinib, however, current methodology involves burdensome overnight urine collection.

Methods

To determine whether the simpler urine protein:creatinine ratio (UPCR) calculated from spot urine samples could be accurately used for proteinuria monitoring in patients receiving lenvatinib, we evaluated the correlation between UPCR and 24-hour urine protein results from the phase 3 REFLECT study. Paired data (323 tests, 154 patients) were analysed.

Results

Regression analysis showed a statistically significant correlation between UPCR and 24-hour urine protein (R²: 0.75; P < 2 × 10^-16). A UPCR cut-off value of 2.4 had 96.9% sensitivity, 82.5% specificity for delineating between grad

SUBMITTER: Evans TRJ 

PROVIDER: S-EPMC6738107 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature