16/18 genotyping in triage of persistent human papillomavirus infections with negative cytology in the English cervical screening pilot.

ABSTRACT:

Background

In the English pilot of primary cervical screening with high-risk human papillomavirus (HR-HPV), we exploited natural viral clearance over 24 months to minimise unnecessary referral of HR-HPV+ women with negative cytology. Three laboratories were permitted to use 16/18 genotyping to select women for referral at 12-month recall. We estimated the clinical impact of this early genotyping referral.

Methods

The observed numbers of women referred to colposcopy and with detected high-grade cervical intraepithelial neoplasia (CIN2+), and of women who did not attend early recall in the three laboratories were compared with those estimated to represent a situation without an early genotyping referral. The 95% confidence intervals (CI) for the differences between the protoco

SUBMITTER: Rebolj M 

PROVIDER: S-EPMC6738108 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature