Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis.

ABSTRACT:

Background

Telomeres, repetitive DNA capping ends of eukaryotic chromosomes, are important in the maintenance of genomic integrity. Perturbed telomeres are common features of many human malignancies, including colorectal cancer.

Methods

Telomere length (TL), measured by a Monochrome Multiplex Real-Time qPCR, was investigated in tumour tissues, adjacent mucosa, and blood from patients with colorectal cancer with different clinicopathological features and its impact on patient survival. TL was also measured in a limited number of liver metastases, non-cancerous liver tissues or corresponding tissues from the same patients.

Results

TL in tumour tissues was shorter than in the adjacent mucosa (P < 0.0001). Shorter TL was observed in tumours with lower stage than in those

SUBMITTER: Kroupa M 

PROVIDER: S-EPMC6738117 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature