Catch Me if You Can: Streptococcus pyogenes Complement Evasion Strategies.

ABSTRACT: The human host has evolved elaborate protection mechanisms to prevent infection from the billions of microorganisms to which it host is exposed and is home. One of these systems, complement, is an evolutionary ancient arm of innate immunity essential for combatting bacterial infection. Complement permits the efficient labelling of bacteria with opsonins, supports phagocytosis, and facilitates phagocyte recruitment to the site of infection through the production of chemoattractants. However, it is by no means perfect, and certain organisms engage in an evolutionary arms race with the host where complement has become a major target to promote immune evasion. Streptococcus pyogenes is a major human pathogen that causes significant morbidity and mortality globally. S. pyogenes is also a member

SUBMITTER: Laabei M 

PROVIDER: S-EPMC6738146 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature