AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech.

ABSTRACT: Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of these proteins significantly increases after bacterial infection; however, the mechanisms by which they regulate the innate immune response are still poorly defined. Here, we evaluate the effect of bacterial lipopolysaccharide injection on the expression pattern of these genes and the interrelation between them during innate immune response in the medicinal leech, an invertebrate model with a simple anatomy and a marked similarity with vertebrates in inflammatory processes. Collectively, prokaryotic-eukaryotic co-cultures and in vivo infection assays suggest that RNASET2

SUBMITTER: Baranzini N 

PROVIDER: S-EPMC6738156 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature