The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials.

ABSTRACT: The human gut microbiota gained tremendous importance in the last decade as next-generation technologies of sequencing and multiomics analyses linked the role of the microbial communities to host physiology and pathophysiology. A growing number of human pathologies and diseases are linked to the gut microbiota. One of the main mechanisms by which the microbiota influences the host is through its interactions with the host immune system. These interactions with both innate and adaptive host intestinal and extraintestinal immunity, although usually commensalistic even mutualistic with the host, in some cases lead to serious health effects. In the case of allogenic hematopoietic stem cell transplantation (allo-HSCT), the disruption of the intestinal microbiota diversity is associated with acu

SUBMITTER: Noor F 

PROVIDER: S-EPMC6738217 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature