Future technologies for monitoring HIV drug resistance and cure.

ABSTRACT:

Purpose of review

Sensitive, scalable and affordable assays are critically needed for monitoring the success of interventions for preventing, treating and attempting to cure HIV infection. This review evaluates current and emerging technologies that are applicable for both surveillance of HIV drug resistance (HIVDR) and characterization of HIV reservoirs that persist despite antiretroviral therapy and are obstacles to curing HIV infection.

Recent findings

Next-generation sequencing (NGS) has the potential to be adapted into high-throughput, cost-efficient approaches for HIVDR surveillance and monitoring during continued scale-up of antiretroviral therapy and rollout of preexposure prophylaxis. Similarly, improvements in PCR and NGS are resulting in higher throughput single g

SUBMITTER: Parikh UM 

PROVIDER: S-EPMC6738332 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature