Differential Associations Between Volumes of Atrophic Cortical Brain Regions and Memory Performances in Early and Late Mild Cognitive Impairment.

ABSTRACT:

Background

Early and late mild cognitive impairment (MCI) patients have been reported to have a distinctive prognosis of converting to Alzheimer's disease.

Objective

To evaluate the difference in gray matter volume and assess the association between cognitive function evaluated by comprehensive cognitive function test, and cortical thickness across healthy controls (HCs) (n = 37), early (n = 30), and late MCI patients (n = 35).

Methods

Differences in gray matter volume were evaluated by whole brain voxel-based morphometry across the groups. Multiple regression analysis was used to analyze group by memory performance interactions for the normalized gray matter volume.

Results

The early MCI group showed reduced gray matter volume in the right

SUBMITTER: Kang DW 

PROVIDER: S-EPMC6738351 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature