Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.

ABSTRACT: Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described mainly because cellular senescence was defined as a permanent cell cycle arrest. Nevertheless, neurons with features of senescence have been described in old rodent and human brains. In this study we characterized an in vitro model useful to study the molecular basis of senescence of primary rat cortical cells that recapitulates senescent features described in brain aging. We found that in long-term cultures, rat primary cortical neurons displayed features of cellular se

SUBMITTER: Moreno-Blas D 

PROVIDER: S-EPMC6738425 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature