Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index.

ABSTRACT: To realize an individual-level risk evaluation of progression of early Alzheimer's disease (AD), we applied an AD resemblance atrophy index (AD-RAI) to differentiate the subjects at risk of progression from normal subjects (NC) to mild cognitive impairment (MCI) and from MCI to AD. We included 183 subjects with a two-year follow-up: 50 NC stable (NCs), 23 NC-to-MCI converters (NCc), 50 MCI stable (MCIs), 35 MCI-to-AD converters (MCIc), 25 AD stable (ADs). ANCOVA analyses were used to identify baseline brain atrophy in converters compared with non-converters. To explore the relative merits of AD-RAI over individual regional volumetric measures in prediction of disease progression, we searched for the optimal cutoff for each measure in logistic regressions and plotted the longitudinal trajec

SUBMITTER: Zhao L 

PROVIDER: S-EPMC6738429 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature