Role of dynamic nuclear deformation on genomic architecture reorganization.

ABSTRACT: Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals. The inverted nuclear architecture found in adult mouse rod cells is formed through the reorganization of the conventional architecture during terminal differentiation. However, the mechanisms underlying these changes remain largely unknown. Here, we found that the dynamic deformation of nuclei via actomyosin-mediated contractility contributes to chromocenter clustering and promotes genomic architecture reorganization during differentiation by conducting an in cellulo experiment coupled with phase-field modeling. Similar patterns of dynamic deformat

SUBMITTER: Seirin-Lee S 

PROVIDER: S-EPMC6738595 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature