The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?

ABSTRACT:

Objective

The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the premature termination of the Women's Health Initiative.

Method

The KEEPS was a randomized, double-blinded, placebo-controlled trial to test the hypothesis that initiation of HT (oral conjugated equine estrogens [o-CEE] or transdermal 17β-estradiol [t-E2]) in healthy, recently postmenopausal women (n = 727) would slow the progression of atherosclerosis as measured by changes in carotid artery intima-media thickness (CIMT).

Results

After 4 years, neither HT affected the rate of increase in CIMT. There was a trend for reduced accumulation of cor

SUBMITTER: Miller VM 

PROVIDER: S-EPMC6738629 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature