The Role of Interferon-λ Locus Polymorphisms in Hepatitis C and Other Infectious Diseases.

ABSTRACT: Since its discovery in 2003, the type III interferon-λ (IFN-λ) family has been found to contribute significantly to the host response to infection. Whilst IFN-λ shares many features with type I IFN induction and signalling pathways, the tissue-specific restricted expression of its receptor, IL28RA, makes IFN-λ a major mediator of host innate immunity in tissues and organs with a high epithelial cell content. Host susceptibility and responses to infection are known to be heterogeneous, and the identification of common genetic variants linked to disease outcome by genome-wide association studies (GWAS) has underscored the significance of host polymorphisms in responses to infection. Several such GWAS have highlighted the IFN-λ locus on chromosome 19q13 as an area of genetic variation signifi

SUBMITTER: Griffiths SJ 

PROVIDER: S-EPMC6738896 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature