Second primary malignancy in patients with esophageal adenocarcinoma and squamous cell carcinoma.

ABSTRACT: There have been no studies on implementing effective screening models for esophageal adenocarcinoma and squamous cell carcinoma survivors. We used a proportional subdistribution hazards model to estimate second primary malignancy risks among patients with esophageal adenocarcinoma and squamous cell carcinoma. We validated models using a bootstrap cross-validation method and performed decision curve analysis to evaluate their clinical utility. Age group and SEER historic stage were significantly associated with second primary malignancy risk after diagnosis of esophageal adenocarcinoma and squamous cell carcinoma. Saving positive lymph nodes and distant metastasis were significant factors in the adenocarcinoma group, and marital status, tumor location, and chemotherapy were significant fact

SUBMITTER: Zhang G 

PROVIDER: S-EPMC6738979 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature