Smooth Muscle Cell-Specific Disruption of the BBSome Causes Vascular Dysfunction.

ABSTRACT: The BBSome-a complex consisting of 8 Bardet-Biedl syndrome proteins-is involved in the regulation of various cellular processes. Recently, the BBSome complex has emerged as an important regulator of cardiovascular function with implications for disease. In this study, we examined the role of the BBSome in vascular smooth muscle and its effects on the regulation of cardiovascular function. Smooth muscle-specific disruption of the BBSome through tamoxifen-inducible deletion of Bbs1 gene-a critical component of the BBSome complex-reduces relaxation and enhances contractility of vascular rings and increases aortic stiffness independent of changes in arterial blood pressure. Mechanistically, we demonstrate that smooth muscle Bbs1 gene deletion increases vascular angiotensinogen ge

SUBMITTER: Reho JJ 

PROVIDER: S-EPMC6739154 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature