Estrogen Receptor-β Mediates Estradiol-Induced Pregnancy-Specific Uterine Artery Endothelial Cell Angiotensin Type-2 Receptor Expression.

ABSTRACT: The pregnancy-augmented uterine vasodilation is linked to increased AT₂R (angiotensin type-2 receptor) that mediates the vasodilatory effects of angiotensin II. However, the mechanisms controlling AT₂R expression during pregnancy remain unclear. Estrogens are known to play a role in vascular adaptations during pregnancy. We hypothesized that estrogen stimulates uterine artery AT₂R expression via ER (estrogen receptor)-β-dependent transcription in a pregnancy-specific endothelium-dependent manner. Plasma estradiol levels increased and peaked in late pregnancy and returned to prepregnant levels post-partum, correlating with uterine artery AT₂R and ERβ upregulation. Estradiol stimulated AT₂R mRNA expression in endothelium-intact but not e

SUBMITTER: Mishra JS 

PROVIDER: S-EPMC6739159 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature