Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair.

ABSTRACT: Inferior anterior cruciate ligament (ACL) structural properties may inadequately restrain tibiofemoral joint motion following surgery, contributing to the increased risk of post-traumatic osteoarthritis. Using both a direct measure of ACL linear stiffness and an in vivo magnetic resonance imaging (MRI) T₂ *-based prediction model, we hypothesized that cartilage damage and ACL stiffness would increase over time, and that an inverse relationship between cartilage damage and ACL stiffness would emerge at a later stage of healing. After either 6, 12, or 24 weeks (w) of healing after ACL repair, ACL linear stiffness was determined from the force-displacement relationship during tensile testing ex vivo and predicted in vivo from the MRI T₂ *-based multiple linear regression

SUBMITTER: Beveridge JE 

PROVIDER: S-EPMC6739195 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature