Population-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain.

ABSTRACT: To identify novel loci that affect cognitive decline in older adults free of dementia, we conducted genome-wide and gene-based meta-analyses on longitudinal slopes of 5 cognitive domains (memory, executive function, language, attention/processing speed, and visuospatial ability) derived from 2 population-based cohorts. For decline over time in each cognitive domain, we normalized intraindividual slopes within each cohort, accounting for baseline age, sex, and years of education. Normalized slope for each domain was used in cohort-specific genome-wide analyses after including top principal components as covariates followed by genome-wide and gene-based meta-analyses. Both analyses revealed a novel WDFY2 locus at genome-wide (p = 3.37E-08) and gene-wide (p = 7.10E-07) significance levels for

SUBMITTER: Kamboh MI 

PROVIDER: S-EPMC6739197 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature