Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function.

ABSTRACT: Cytokine-induced memory-like (CIML) NK cells generated in response to proinflammatory cytokines in vitro and in vivo can also be generated by vaccination, exhibiting heightened responses to cytokine stimulation months after their initial induction. Our previous study demonstrated that in vitro human NK cell responses to inactivated influenza virus were also indirectly augmented by very low doses of IL-15, which increased induction of myeloid cell-derived cytokine secretion. These findings led us to hypothesize that IL-15 stimulation could reveal a similar effect for active influenza vaccination and influence CIML NK cell effector functions. In this study, 51 healthy adults were vaccinated with seasonal influenza vaccine, and PBMC were collected before and up to 30 d after vaccination. Myel

SUBMITTER: Wagstaffe HR 

PROVIDER: S-EPMC6739223 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature