The Changing Role of Gene-Expression Profiling in the Era of De-escalating Adjuvant Chemotherapy in Early-Stage Breast Cancer.

ABSTRACT:

Purpose

We assessed the recent trends in the administration of adjuvant chemotherapy thereby evaluating the role of the 70-gene signature (70-GS) testing in decision-making in the systemic treatment of patients with lymph node negative (N0) and lymph node positive (N+) breast cancer.

Methods

Patients with a national guideline directed indication for 70-GS use treated between 2013 and 2016 were selected from the Netherlands Cancer Registry. Time trends in the administration of adjuvant chemotherapy were evaluated within guideline- and age-delineated subgroups. The influence of the 70-GS on chemotherapy use was assessed with logistic regression.

Results

During the study period, the overall administration of adjuvant chemotherapy decreased from 49 to 23% and 70-GS use in

SUBMITTER: van Steenhoven JEC 

PROVIDER: S-EPMC6739278 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature