Evaluation of (-)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake.

ABSTRACT: Data from dietary intervention studies suggest that intake of (-)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (-)-epicatechin metabolites (SREM), particularly (-)-epicatechin-3'-glucuronide, (-)-epicatechin-3'-sulfate and 3'-O-methyl-(-)-epicatechin-5-sulfate (SREM_B), as flavan-3-ol and (-)-epicatechin intake. SREM_B in urine proved to be a specific indicator of (-)-epicatechin intake, showing also a strong correlation with the amount of (-)-epicatechin ingested (R²: 0.86 (95% CI 0.8l

SUBMITTER: Ottaviani JI 

PROVIDER: S-EPMC6739331 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature