Metabolomics Deciphered Metabolic Reprogramming Required for Biofilm Formation.

ABSTRACT: Biofilm formation plays a key role in many bacteria causing infections, which mostly accounts for high-frequency infectious recurrence and antibiotics resistance. In this study, we sought to compare modified metabolism of biofilm and planktonic populations with UTI89, a predominant agent of urinary tract infection, by combining mass spectrometry based untargeted and targeted metabolomics methods, as well as cytological visualization, which enable us to identify the driven metabolites and associated metabolic pathways underlying biofilm formation. Surprisingly, our finding revealed distinct differences in both phenotypic morphology and metabolism between two patterns. Furthermore, we identified and characterized 38 differential metabolites and associated three metabolic pathways involving g

SUBMITTER: Lu H 

PROVIDER: S-EPMC6739361 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature