Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions.

ABSTRACT: Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggeri

SUBMITTER: Bornhorst D 

PROVIDER: S-EPMC6739419 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature