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Myopia genetics in genome-wide association and post-genome-wide association study era.

ABSTRACT: Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era.

SUBMITTER: Liao X 

PROVIDER: S-EPMC6739571 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Myopia genetics in genome-wide association and post-genome-wide association study era.

Liao Xuan X   Tan Qing-Qing QQ   Lan Chang-Jun CJ  

International journal of ophthalmology 20190918 9

Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has remained challenging. This review provides a brief summary of the main focus on the advantages and limitations of GWAS of myopia, with potential strategies that may contribute to further insight into the genetics of myopia in the post-GWAS or omics era  ...[more]

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