A Hybrid Ensemble Approach for Identifying Robust Differentially Methylated Loci in Pan-Cancers.

ABSTRACT: DNA methylation is a widely investigated epigenetic mark that plays a vital role in tumorigenesis. Advancements in high-throughput assays, such as the Infinium 450K platform, provide genome-scale DNA methylation landscapes in single-CpG locus resolution, and the identification of differentially methylated loci has become an insightful approach to deepen our understanding of cancers. However, the situation with extremely unbalanced numbers of samples and loci (approximately 1:1,000) makes it rather difficult to explore differential methylation between the sick and the normal. In this article, a hybrid approach based on ensemble feature selection for identifying differentially methylated loci (HyDML) was proposed by incorporating instance perturbation and multiple function models. Experiment

SUBMITTER: Tian Q 

PROVIDER: S-EPMC6739624 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature