Hematopoietic Chimera in a Male Blood Donor and His Dizygotic Twin Sister.

ABSTRACT: Twin hematopoietic chimera in humans is a phenomenon that was discovered accidentally and the prevalence of which remains unclear. The resolution of chimera cases requires studying family medical records, data analysis, and investigations of hematopoietic cells and cells from other tissues. The interactions among ABO, Lewis, and secretor histo-blood group systems are explored to resolve cases of hematopoietic chimera. Here we report a rare case of hematopoietic chimera where twins present a mixed field reaction in the ABO, Rh, and Kidd red blood cell phenotyping. Using red blood cells separated from the mixed field as well as molecular approaches and investigations of family members, we identify inconsistent genotypes with the Mendelian inheritance pattern when comparing the peripheral blo

SUBMITTER: Miola MP 

PROVIDER: S-EPMC6739710 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature