A Genetic Approach to the Association Between PCSK9 and Sepsis.

ABSTRACT:

Importance

Whether the PCSK9 gene is associated with the progress from infection to sepsis is unknown to date.

Objective

To test the associations between PCSK9 genetic variants, a PCSK9 genetic risk score (GRS), or genetically estimated PCSK9 expression levels and the risk of sepsis among patients admitted to a hospital with infection.

Design, setting, and participants

This retrospective cohort study used deidentified electronic health records to identify patients admitted to Vanderbilt University Medical Center, Nashville, Tennessee, with infection. Patients were white adults, had a code indicating infection from the International Classification of Diseases, Ninth Revision, Clinical Modification, or the International Statistical Classification of Diseases, Tenth Revi

SUBMITTER: Feng Q 

PROVIDER: S-EPMC6739725 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature