Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses.

ABSTRACT:

Objectives

This study aimed to identify the possible effects of Myc and 8q24 polymorphisms on bleeding complications in patients who maintained international normalized ratio (INR) of 2.0-3.0 with warfarin therapy after cardiac valve replacement.

Methods

Twenty-five single nucleotide polymorphisms were analyzed, including VKORC1, CYP2C9, Myc, and 8q24. Univariate and multivariate analyses were conducted to evaluate the associations between genetic polymorphisms and bleeding complications. Attributable risk and the number needed to genotype (NNG) were also calculated to evaluate the potential clinical value of genotyping.

Results

We included 142 patients, among whom 21 experienced bleeding complications. Multivariate models showed that patie

SUBMITTER: Yee J 

PROVIDER: S-EPMC6739803 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature