Complex relationships between perfluorooctanoate, body mass index, insulin resistance and serum lipids in young girls.

ABSTRACT: BACKGROUND:Perfluorooctanoate (PFOA) has been used extensively in the manufacture of both commercial and household products. PFOA serum concentrations have been associated with adverse health effects, including lower body mass in children and infants. OBJECTIVE:To determine if there is an association between serum PFOA concentration and body mass, serum insulin and lipid profile in exposed young girls. METHODS:We conducted a cross-sectional study of PFAS environmental biomarkers and insulin resistance in 6 to 8 year-old girls from Greater Cincinnati (n=353). In 2004-2006, blood samples were obtained to measure polyfluoroalkyl substances (PFAS), fasting insulin, glucose and lipids. Clinical exams included anthropometric measurements and pubertal maturation staging. Linear regression and med

SUBMITTER: Fassler CS 

PROVIDER: S-EPMC6739842 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature