Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension.

ABSTRACT:

Background

Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants.

Methods

AMBITION was an event-driven, double-blind study in which participants were randomized 2:1:1 to once-daily initial combination therapy with ambrisentan 10 mg plus tadalafil 40 mg, ambrisentan 10 mg plus placebo, or tadalafil 40 mg plus placebo. In this pre-specified subgroup analysis, we compared the efficacy data between those with functional class (FC) II vs. FC III symptoms at baseline.

Results

This analysis included 500 participants in the p

SUBMITTER: White RJ 

PROVIDER: S-EPMC6739949 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature