Discordant amyloid-β PET and CSF biomarkers and its clinical consequences.

ABSTRACT:

Background

In vivo, high cerebral amyloid-β load has been associated with (i) reduced concentrations of Aβ₄₂ in cerebrospinal fluid and (ii) increased retention using amyloid-β positron emission tomography. Although these two amyloid-β biomarkers generally show good correspondence, ~ 10-20% of cases have discordant results. To assess the consequences of having discordant amyloid-β PET and CSF biomarkers on clinical features, biomarkers, and longitudinal cognitive trajectories.

Methods

We included 768 patients (194 with subjective cognitive decline (SCD), 127 mild cognitive impairment (MCI), 309 Alzheimer's dementia (AD), and 138 non-AD) who were categorized as concordant-negative (n = 315, 41%), discordant (n = 97, 13%), or concordant-positive (n = 356, 46%) based

SUBMITTER: de Wilde A 

PROVIDER: S-EPMC6739952 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature