Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies.

ABSTRACT:

Background

Very little is known for the direction or causality of the relationship between lifetime sleep experiences and in vivo Alzheimer's disease (AD) pathologies. This study aimed to examine the relationship between sleep experiences during the young adulthood, midlife, and late-life periods and in vivo cerebral beta-amyloid (Aβ) deposition and AD signature regional neurodegeneration in cognitively normal (CN) old adults.

Methods

This study included 202 CN old adults who participated in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) study. All participants underwent a comprehensive clinical assessment, [¹¹C] Pittsburgh Compound B positron emission tomography (PET), [¹⁸F] Fluorodeoxyglucose-PET, an

SUBMITTER: Choe YM 

PROVIDER: S-EPMC6739958 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature