Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.

ABSTRACT:

Background

Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic options. Cell adhesion molecules play pivotal roles in the growth and progression of glial tumors. Roles of the adhesion molecules on glia (AMOG) and L1CAM (L1) in glioma cells have been shown to correlate with tumorigenesis: Increased expression of L1 and decreased expression of AMOG correlate with degree of malignancy.

Methods

We evaluated the interdependence in expression of these molecules by investigating the role of AMOG in vitro via modulation of L1 expression and analyzing apoptosis and cell senescence of glioma cells.

Results

Immunohistochemical staining of normal human cortical and glioma tissue microarrays demonstra

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC6739972 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature