E6 and E7 gene polymorphisms in human papillomavirus Type-6 identified in Southwest China.

ABSTRACT:

Background

Human papillomavirus type-6 (HPV6) is the major etiological agent of anogenital warts both men and women. The present study aimed to characterize the genetic diversity among HPV6 in Southwest China, and to investigate the origin of, selective pressure experienced by, and impact of the resultantly identified genetic variants on the HPV6 secondary structure.

Methods

Phylogenetic trees were constructed by Maximum-likelihood and the Kimura 2-parameters methods by Molecular Evolutionary Genetics Analysis version 6.0. The diversity of secondary structure was analyzed by PSIPred software. The selection pressures acting on the E6/E7 genes were estimated by Phylogenetic Analyses by Maximum Likelihood version 4.8 software.

Results

HPV6 was the most prevalent low risk

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6740006 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature