Maximal standard uptake values of ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients.

ABSTRACT:

Background

This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels in de novo metastatic nasopharyngeal carcinoma (NPC) patients.

Methods

From December 2006 to December 2016, 253 de novo metastatic NPC patients assessed by PET/ computed tomography were involved in current study. SUVmax-T, SUVmax-N, and SUVmax-M referred to the SUVmax at the primary tumor, cervical lymph nodes, and metastatic lesions respectively. Overall survival (OS) was the primary endpoint.

Result

Patients who died during the follow-up had significantly higher SUVmax-N, SUVmax-M, and EBV DNA level than those in the patients who were al

SUBMITTER: Sun XS 

PROVIDER: S-EPMC6740035 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature