Unique DNA Methylation Profiles Are Associated with cis-Variation in Honey Bees.

ABSTRACT: DNA methylation is an important epigenetic modification that mediates diverse processes such as cellular differentiation, phenotypic plasticity, and genomic imprinting. Mounting evidence suggests that local DNA sequence variation can be associated with particular DNA methylation states, indicating that the interplay between genetic and epigenetic factors may contribute synergistically to the phenotypic complexity of organisms. Social insects such as ants, bees, and wasps have extensive phenotypic plasticity manifested in their different castes, and this plasticity has been associated with variation in DNA methylation. Yet, the influence of genetic variation on DNA methylation state remains mostly unknown. Here we examine the importance of sequence-specific methylation at the genome-wide le

SUBMITTER: Yagound B 

PROVIDER: S-EPMC6740151 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature