The Study of Release Mechanisms for Drug in Cyclodextrin Metal-Organic Frameworks.

ABSTRACT: γ-Cyclodextrin metal-organic frameworks (γCDMOF) recently emerged as biofriendly, highly porous, and crystalline materials with potential applications in drug delivery. However, little is known about their drug entrapment and release characteristics, which are key parameters in the design of drug carriers. The macroscopic properties of a material are determined by its microstructure. Thus, the characteristics of the constitutive units of the cubic crystalline γCDMOF determine their drug loading and release behaviors. In this study, the release profile of prednisolone (PNS) form γCDMOF was predicted, and the mechanism was analyzed based on the γCDMOF molecular structure. For the first time, experimental, molecular simulation, and mathematical modeling methods were combined to gain insights

SUBMITTER: Liu C 

PROVIDER: S-EPMC6740174 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature