Presynaptic depression of glutamatergic synaptic transmission by D1-like dopamine receptor activation in the avian basal ganglia.

ABSTRACT: Vocal behavior in songbirds exemplifies a rich integration of motor, cognitive, and social functions that are shared among vertebrates. As a part of the underlying neural substrate, the song system, the anterior forebrain pathway (AFP) is required for song learning and maintenance. The AFP resembles the mammalian basal ganglia-thalamocortical loop in its macroscopic organization, neuronal intrinsic properties, and microcircuitry. Area X, the first station in the AFP, is a part of the basal ganglia essential for vocal learning. It receives glutamatergic inputs from pallial structures and sends GABAergic outputs to thalamic structures. It also receives dense dopaminergic innervation from the midbrain. The role of this innervation is essentially unknown. Here we provide evidence that dopamine

SUBMITTER: Ding L 

PROVIDER: S-EPMC6740340 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature