Distribution and properties of functional postsynaptic kainate receptors on neocortical layer V pyramidal neurons.

ABSTRACT: The distribution of glutamate receptor subtypes on the surface of neurons is highly relevant for synaptic transmission and signal processing. In the present study we investigated the location and properties of functional kainate receptors (KARs) on the somatodendritic membrane of rat neocortical layer V pyramidal neurons. Infrared-guided laser stimulation was used to apply glutamate photolytically to the soma and various sites along the apical dendrite. Electrical currents, resulting from the activation of pharmacologically isolated KARs, were measured by whole-cell patch-clamp recording. In addition, KARs on somatic and dendritic outside-out patches were activated while still within the brain tissue. We found that functional KARs are located on the entire somatodendritic membrane that was

SUBMITTER: Eder M 

PROVIDER: S-EPMC6740632 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature