Separation-induced receptor changes in the hippocampus and amygdala of Octodon degus: influence of maternal vocalizations.

ABSTRACT: Relatively little is known about the basic mechanisms that play a role in the vulnerability of the developing brain toward adverse environmental influences. Our study in the South American rodent Octodon degus revealed that repeated brief separation from the parents and exposure to an unfamiliar environment induces in the hippocampal formation of male and female pups an upregulation of D1 and 5-HT1A receptor density in the stratum radiatum and stratum lacunosum moleculare of the CA1 region. In the CA3 region, only the 5-HT1A receptors were upregulated; no changes were observed for D1 receptors in this region. GABA(A) receptor density in the hippocampus and amygdala was downregulated (nonsignificant trend) after parental separation. The acoustic presence of the mother during parental separa

SUBMITTER: Ziabreva I 

PROVIDER: S-EPMC6741186 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature