Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

ABSTRACT:

Background

The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear.

Methods

We randomly assigned patients with moderate-to-severe ARDS (defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure [PEEP] of ≥8 cm of water) to a 48-hour continuous infusion of cisatracurium with concomitant deep sedation (intervention group) or to a usual-care approach without routine neuromuscular blockade and with lighter sedation targets (control group). The same mechanical-ventilation strategies were used in both groups, including a strategy involving a high PEEP. The primary end point w

SUBMITTER: National Heart, Lung, and Blood Institute PETAL Clinical Trials Network 

PROVIDER: S-EPMC6741345 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature