Modulation of biomimetic mineralization of collagen by soluble ectodomain of discoidin domain receptor 2.

ABSTRACT: Collagen fibrils serve as the major template for mineral deposits in both biologically derived and engineered tissues. In recent years certain non-collagenous proteins have been elucidated as important players in differentially modulating intra vs. extra-fibrillar mineralization of collagen. We and others have previously shown that the expression of the collagen receptor, discoidin domain receptor 2 (DDR2) positively correlates with matrix mineralization. The objective of this study was to examine if the ectodomain (ECD) of DDR2 modulates intra versus extra-fibrillar mineralization of collagen independent of cell-signaling. For this purpose, a decellularized collagenous substrate, namely glutaraldehyde fixed porcine pericardium (GFPP) was subjected to biomimetic mineralization protocols. G

SUBMITTER: Farzadi A 

PROVIDER: S-EPMC6741439 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature