Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation.

ABSTRACT: The factors controlling the specification and subsequent differentiation of sensory neurons are poorly understood. Data from embryological manipulations suggest that either sensory neuron fates are specified by the targets they encounter or sensory neurons are considerably more "plastic" with respect to specification than are neurons of the CNS. The prevailing view that sensory neurons are specified late in development is not consistent, however, with the directed outgrowth of sensory neurons to their targets and the characteristic spatial distribution of sensory neuron fates within the peripheral ganglia. To address when in development different classes of sensory neurons can first be distinguished, we investigated the interactions of early dorsal root ganglia neurons with the extracellul

SUBMITTER: Guan W 

PROVIDER: S-EPMC6741987 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature