Wide-field spectrally resolved quantitative fluorescence imaging system: toward neurosurgical guidance in glioma resection.

ABSTRACT: In high-grade glioma surgery, tumor resection is often guided by intraoperative fluorescence imaging. 5-aminolevulinic acid-induced protoporphyrin IX (PpIX) provides fluorescent contrast between normal brain tissue and glioma tissue, thus achieving improved tumor delineation and prolonged patient survival compared with conventional white-light-guided resection. However, commercially available fluorescence imaging systems rely solely on visual assessment of fluorescence patterns by the surgeon, which makes the resection more subjective than necessary. We developed a wide-field spectrally resolved fluorescence imaging system utilizing a Generation II scientific CMOS camera and an improved computational model for the precise reconstruction of the PpIX concentration map. In our model, the tiss

SUBMITTER: Xie Y 

PROVIDER: S-EPMC6742512 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature