Memory improvement in African Americans with amnestic mild cognitive impairment.

ABSTRACT:

Objective

Amnestic mild cognitive impairment (aMCI) has an uncertain course. Valid methods to evaluate memory change will best identify predictors of course. This issue is especially relevant to older persons in minority groups, who may have encountered life course factors that adversely affect cognition.

Methods/design

Growth curve mixture models were used to identify trajectories of memory test scores obtained every 6 months over 2 years in 221 African Americans with aMCI.

Results

Participants sorted into two classes, with clinically and statistically significant differences in memory scores over time. Class 1 (n = 28 [14.7%]) had sustained improved scores. Class 2 (n = 162 [85.3%]) scores remained low, fluctuated, or declined. Class 1 had better baseline cognition

SUBMITTER: Rovner BW 

PROVIDER: S-EPMC6742531 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature