Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

ABSTRACT:

Rationale

PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate PGC1α expression as a therapy, for instance, causing cardiomyopathy.

Objective

To determine whether a fine-tuning of PGC1α expression is essential for cardiac homeostasis in a context-dependent manner.

Methods and results

Moderate cardiac-specific PGC1α overexpression through a ROSA26 locus knock-in strategy was utilized in WT (wild type) mice and in G3Terc^-/- (third generation of telomerase deficient; hereafter as G3) mouse model, respectively. Ultrastructure, mitochondrial stress, echocardiographic, and a variety of biological approaches we

SUBMITTER: Zhu X 

PROVIDER: S-EPMC6742548 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature