Neuropathological lesions in the very old: results from a large Brazilian autopsy study.

ABSTRACT:

Objective

To compare neuropathological correlates of cognitive impairment between very old and younger individuals from a Brazilian clinicopathological study.

Methods

We assessed the frequency of neuropathological lesions and their association with cognitive impairment (Clinical Dementia Rating scale ≥0.5) in the 80 or over age group compared to younger participants, using logistic regression models adjusted for sex, race and education.

Results

Except for infarcts and siderocalcinosis, all neuropathological lesions were more common in the 80 or over age group (n = 412) compared to 50-79 year olds (n = 677). Very old participants had more than twice the likelihood of having ≥2 neuropathological diagnoses than younger participants (OR = 2.66, 95% CI = 2.03-3.50). Neurof

SUBMITTER: Suemoto CK 

PROVIDER: S-EPMC6742578 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature