Ontology highlight
ABSTRACT:
SUBMITTER: Vandoorne T
PROVIDER: S-EPMC6742665 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190912 1
Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (iPSCs) versus iPSC-derived MNs and subsequently compared MNs from ALS patients carrying FUS mutations to their CRISPR/Cas9-corrected counterparts. We discovered that human iPSCs und ...[more]