Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses.

ABSTRACT: The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using an agent-based model of the germinal center reaction, we studied the impact of antibody feedback on kinetics and efficiency of a germinal center. Our simulations predict that high feedback of antibodies from germinal centers reduces the production of plasma cells and subsequently the efficiency of the germinal center reaction by promoting earlier termination. Affinity maturation is only weakly improved by increased antibody feedback and ultimately interrupted because of premat

SUBMITTER: Arulraj T 

PROVIDER: S-EPMC6742702 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature