Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks.

ABSTRACT: Spontaneous network activity plays a fundamental role in the formation of functional networks during early development. The landmark of this activity is the recurrent emergence of intensive time-limited network bursts (NBs) rapidly spreading across the entire dissociated culture in vitro. The main excitatory mediators of NBs are glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) and N-Methyl-D-aspartic-acid receptors (NMDARs) that express fast and slow ion channel kinetics, respectively. The fast inhibition of the activity is mediated through gamma-aminobutyric acid type A receptors (GABA_ARs). Although the AMPAR, NMDAR and GABA_AR kinetics have been biophysically characterized in detail at the monosynaptic level in a

SUBMITTER: Teppola H 

PROVIDER: S-EPMC6742722 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature